Influence of caffeine on melanopsin sensitivity in the retina
Conditions
Interventions
Group 1: Each participant will be exposed to four conditions in random order. These conditions are: DP – dim light (<10 lux) and placebo
DC - dim light (<10 lx) and caffeine
LP – <1000 lux light exposure and placebo, LC – <1000 lux light exposure and caffeine (3.0 mg/kg). The <1000 lux light will be provided by room overhead illumination throughout the protocol. The value
Sponsors
Centre for ChronobiologyTransfaculty Research Platform Molecular and Cognitive Neurosciences (MCN)Psychiatric Hospital of the University of Basel (UPK)
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: BMI 29.9; Chronotoype (Morningness-Evening Questionnaire) (69); Sleep quality (Pittsburgh Sleep Quality Index, PSQI) (>5); Substance abuse (Alcohol Use Disorders Identification Test, AUDIT) (>7); Depressive symptoms (Center for Epidemiologic Studies Depression scale, CES-D) (>17); Habitual caffeine intake consumption (Caffeine intake questionnaire) (300 mg/day)
Exclusion criteria
Exclusion criteria: Schwangerschaft; hormonelle Verhuetungsmittel, BMI 29.9; exklusive Verwendung von Kontaktlinsen; hohe Myopie; Zeitzonenreisen in den letzten drei Monaten; Schichtarbeit in den letzten drei Monaten; Teilnahme in anderen klinischen Studien; Koffeinempfindlichkeit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melanopsin sensitivity (assayed using the pupillary light reflex) | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary melatonin, mean pupil size, subjective sleepiness, vigilance performance | — |
Countries
Switzerland
Contacts
Public ContactManuel Spitschan
Centre for ChronobiologyTransfaculty Research Platform Molecular and Cognitive Neurosciences (MCN)Psychiatric Hospital of the University of Basel (UPK)
Outcome results
None listed