F32 F33
Conditions
Interventions
Group 1: ECT with central parietal positioning (at least 5 treatments with a frequency of 1-2 per week, afterwards change to right unilateral positioning), the number of treatments after the change wi
Sponsors
LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Ages between 40 and 80 years old - Suffering from a severe major depression (Symptom criteria based on ICD-10) - Resistence to at least two antidepressive medications, operationalized though the ATHF (antidepressant treatment history form) - MADRS-score of 30 or above - ability to give informed consent
Exclusion criteria
Exclusion criteria: - contraindication for the necessary anaestheasia - psychoorganic disorders such as epilepsy, Morbus Parkinson, dementia, stroke or traumatic brain injury - addiction disorders - prior treatment with ECT in the index episode - patients unable to provide informed consent (patients under guardianship)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Seizure Quality Parameters - Reduction of depressive Symptoms (operationalized through MADRS) - Changes in cognitive performance (operationalized though the Mini Mental State Test) | — |
Secondary
| Measure | Time frame |
|---|---|
| Medication needed after ECT, psychopathological symptoms and general protocoll of noteworthy events | — |
Countries
Germany
Contacts
Public ContactMilenko Kujovic
LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität
Outcome results
None listed