Neuropsychiatric long term symptoms following COVID-19: Causes, functional correlates and pathomechanisms

Neuropsychiatric long term symptoms following COVID-19: Causes, functional correlates and pathomechanisms - NEULOCO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027230

Enrollment

Registered

2021-11-16

Start date

2021-11-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U09.9! Post-COVID syndrome

Interventions

Group 1: Patients suffering from long-COVID: Neuropsychiatric examination, psychometric questionnaires, cognitive testing, sleep examination using polysomnography, multiple sleep latency test and acti

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Post-COVID syndrome (WHO definition) including neuropsychiatric symptoms; age 18-65 years

Exclusion criteria

Exclusion criteria: Pre-existing cognitive deficits, pre-existing sleep disorder, for MRI investigation: contraindication against magnetic resonance tomography

Design outcomes

Primary

Measure	Time frame
Magnetic resonance spectroscopy signs of disturbed neuronal energy metabolism	—

Secondary

Measure	Time frame
1.) Disturbed sleep architecture in patients with long-COVID compared to subjects with and without previous COVID-19-disease 2.) Clinical symptoms correlate with signs of disturbed neuronal energy metabolism in patients with long-COVID 3.) Genetic differences between subjects with previous COVID-19 with and without long-COVID are indicative of factors predisposing to long-COVID 4.) Exploratively: Differences in microbiome between healthy subjects without previous COVID-19 and subjects after COVID-19 with and without long-COVID	—

Measure

Time frame

1.) Disturbed sleep architecture in patients with long-COVID compared to subjects with and without previous COVID-19-disease 2.) Clinical symptoms correlate with signs of disturbed neuronal energy metabolism in patients with long-COVID 3.) Genetic differences between subjects with previous COVID-19 with and without long-COVID are indicative of factors predisposing to long-COVID 4.) Exploratively: Differences in microbiome between healthy subjects without previous COVID-19 and subjects after COVID-19 with and without long-COVID

—

Countries

Germany

Contacts

Public ContactClaudia Schilling

Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim / Universität heidelberg, Klinik für Psychiatrie und Psychotherapie

claudia.schilling@zi-mannheim.de+49-621-1703-1781

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026