Wheat - A model allergen to better understand food Allergy and intolerance and to improve the health Care of affected children and adults

Wheat - A model allergen to better understand food Allergy and intolerance and to improve the health Care of affected children and adults - Wheat-A-Baic

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027174

Enrollment

300

Registered

2021-12-06

Start date

2022-01-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T78.1

Interventions

Group 1: The study participants are children and adults with (suspected) wheat allergy or sensitization to wheat and clinical tolerance. In addition, children and adults with (suspected) other food al

Eligibility

Sex/Gender

All

Age

6 Months to 67 Years

Inclusion criteria

Inclusion criteria: Children and adults with (A) (suspected) wheat allergy OR (B) sensitization to wheat with clinical tolerance OR (C) food allergy without wheat sensitization. Written informed consent from the study participant, or guardian in the case of minors. Participants/parents are linguistically and mentally capable of understanding the intention of the study.

Exclusion criteria

Exclusion criteria: - According to the assessment of the responsible physician, e.g. in case of severe illness (e.g. acute trauma, severe oncological disease, severe renal dysfunction, syndromic disease, clinically relevant cardiovascular disease, pheochromocytoma, autoimmune disease). - Acute infection - Use of antihistamines 3-5 days before oral food provocation - Treatment with beta-blockers and/or ACE inhibitors - Systemic immunosuppression - Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Determination of risk and augmentation factors and natural tolerance development in patients with wheat allergy in childhood and adulthood.	—

Secondary

Measure	Time frame
1. Frequency of immediate-type allergic reactions to wheat in combination with physical exercise in children and adults clinically tolerant to wheat without augmentation. 2. Frequency of clinical development of tolerance in children and adults with wheat allergy. 3. Percentage of children and adults with wheat allergy on diets declared gluten-free. 4. Frequency of immediate-type allergic reactions in wheat allergic individuals due to consumption of products declared gluten-free.	—

Measure

Time frame

1. Frequency of immediate-type allergic reactions to wheat in combination with physical exercise in children and adults clinically tolerant to wheat without augmentation. 2. Frequency of clinical development of tolerance in children and adults with wheat allergy. 3. Percentage of children and adults with wheat allergy on diets declared gluten-free. 4. Frequency of immediate-type allergic reactions in wheat allergic individuals due to consumption of products declared gluten-free.

—

Countries

Germany

Contacts

Public ContactBirgit Kalb

Charité- Universitätsmedizin BerlinKlinik für Pädiatrie m.S. Pneumologie und Immunologie mit Intensivmedizin

weizenprojekt@charite.de030450516467

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026