Determinants of semi-immunity and disease tolerance in malaria

Determinants of semi-immunity and disease tolerance in malaria - DEMIT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027121

Enrollment

350

Registered

2023-01-24

Start date

2021-06-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

B50 B51 B52 B53 B54

Interventions

Group 1: Malaria patients with different levels of semi-immunity and healthy controls will be studied and compared: a) Adult malaria-naïve patients with first-time infection (travellers). currently li

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Diagnosed infection with Plasmodium spp. or control group without infection. - Age 6 months - 17 years (children) or =18 years (adults). - Informed consent available

Exclusion criteria

Exclusion criteria: - Incapacity to consent - Presence of medical reasons that militate against the collection of additional blood volume - Known sickle cell disease - G6PD deficiency - chronic immunological disease - malignant haematological disease

Design outcomes

Primary

Measure	Time frame
The aim of the study is to identify and characterise factors that underlie and influence semi-immunity or disease tolerance. The focus here will be on immunological factors.	—

Secondary

Measure	Time frame
The study is “hypothesis generating” in nature. The endpoints derive from the molecular assessments done with patient materials. Thereby we will primarily investigate differences between the patient groups during and after acute infection with regard to 1) diversity of T cell receptor (TCR) and B cell receptor (BCR) repertoires 2) plasma proteome profiles 3)pre-existing P. falciparum-specific T cells 4) pre-existing anti-CSP and anti-PfEMP-1 antibody repertoire 5) innate and adaptive immune cell types 6) HLA type 7) cytokine profiles 8) the RNA expression profile of immune cells and platelets on single cell level in peripheral blood 9) epigenetic modifications of peripheral immune cells (PBMCs)	—

Measure

Time frame

The study is “hypothesis generating” in nature. The endpoints derive from the molecular assessments done with patient materials. Thereby we will primarily investigate differences between the patient groups during and after acute infection with regard to 1) diversity of T cell receptor (TCR) and B cell receptor (BCR) repertoires 2) plasma proteome profiles 3)pre-existing P. falciparum-specific T cells 4) pre-existing anti-CSP and anti-PfEMP-1 antibody repertoire 5) innate and adaptive immune cell types 6) HLA type 7) cytokine profiles 8) the RNA expression profile of immune cells and platelets on single cell level in peripheral blood 9) epigenetic modifications of peripheral immune cells (PBMCs)

—

Countries

Gabon, Germany

Contacts

Public ContactFlorian Kurth

Charité Universitätsmedizin BerlinKlinik m.S. Infektiologie und Pneumologie

florian.kurth@charite.de030450665023

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026