Influence of a 12-week supplementation with collagen peptides and resistance training on the intracellular signalling pathway of muscular protein biosynthesis as well as ultrastructural and functional adaptations in skeletal muscles

Influence of a 12-week supplementation with collagen peptides and resistance training on the intracellular signalling pathway of muscular protein biosynthesis as well as ultrastructural and functional adaptations in skeletal muscles - Biopsy Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00027112

Enrollment

Registered

2021-11-11

Start date

2020-01-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of resistance training and collagen peptide intake on muscular adaptations in healthy volunteers

Interventions

Group 1: High-load resistance training with collagen peptide supplementation Group 2: High-load resistance training with placebo supplementation

Eligibility

Sex/Gender

Male

Age

18 Years to 29 Years

Inclusion criteria

Inclusion criteria: - Male gender - age between 18-29 - BMI 18.5 - 25 - Physically active: - < 150 minutes/week of moderate-intensity exercise (e.g. 5 x 30 minutes/week) or < 75 minutes/higher-intensity exercise (running, cycling, playing sports). - No regular participation in strength training during the last 12 months - Stable weight and nutritional behaviour (mixed diet) - Informed consent - No contraindications to exercise according to ACSM guidelines - Metabolically healthy

Exclusion criteria

Exclusion criteria: - Regular participation in strength and endurance training during the last 12 months. - Malignant diseases in the past 5 years. - Cardiac disease (e.g. chronic heart disease, arrhythmia, valvular disease, arthritis etc.). Cardiac disease (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis, etc.). - Arterial hypertension (RRsyst > 200 mmHg and/or RRdiast > 105 mmHg) at rest. - Presence of insulin-dependent diabetes mellitus (IDDM). - Presence of a lipometabolic disorder. - Regular intake of medication.

Design outcomes

Primary

Measure	Time frame
Change in mTOR activation / phosphprylation	—

Secondary

Measure	Time frame
All secondary outcomes will be investigated either in the acute study (single strength training session with supplementation) or in the long-term study (12-week): Acute study: - Genome sequencing/transcriptome sequencing-. - Protein activation (AKT, AMPK, FoXo, MuRF-1, MAFbx, PRAS40, ERK1/2, LCB3, LBC I/II, Antrogin-1). Long-term study: - Histological examinations (muscle fibre distribution, muscle cell nucleus density, fibroblast density, satellite cell distribution) - Protein concentrations (AKT, AMPK, FoXo, MuRF-1, MAFbx, PRAS40, ERK1/2, LCB3, LBC I/II, Antrogin-1) - Muscle volume (MRI) - Tendon volume (MRT) - Muscle strength	—

Measure

Time frame

All secondary outcomes will be investigated either in the acute study (single strength training session with supplementation) or in the long-term study (12-week): Acute study: - Genome sequencing/transcriptome sequencing-. - Protein activation (AKT, AMPK, FoXo, MuRF-1, MAFbx, PRAS40, ERK1/2, LCB3, LBC I/II, Antrogin-1). Long-term study: - Histological examinations (muscle fibre distribution, muscle cell nucleus density, fibroblast density, satellite cell distribution) - Protein concentrations (AKT, AMPK, FoXo, MuRF-1, MAFbx, PRAS40, ERK1/2, LCB3, LBC I/II, Antrogin-1) - Muscle volume (MRI) - Tendon volume (MRT) - Muscle strength

—

Countries

Germany

Contacts

Public ContactDaniel König

Institut für Sport und Sportwissenschaft, Albert-Ludwigs-Universität Freiburg

Daniel.Koenig@sport.uni-freiburg.de+497612034542

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026