Analysis of the correlation of serum-biomarker based measures of neurodegeneration and synaptic dysfunction with outcome in patients with delirium and acute encephalopathy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027078

Enrollment

Registered

2021-11-08

Start date

2021-05-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.0 F05.1 F05.8 F05.9

Interventions

Group 1: Asservated blood samples from patients in intensive care units with delirium (case) are analyzed at two time points. The patient is questioned about his condition at a third time point. Group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Delirium: Age >= 18 years, Patient or legal representative gave consent, clinical diagnosis of delirium or acute encephalopathy, screened by CAM-ICU and validated by ICD-10 criteria Controls: Age >= 18 years, Patient or legal representative gave consent

Exclusion criteria

Exclusion criteria: Documented history of dementia, history of intracranial and cardiovascular surgery or recent interfering neurological events within the past year, including stroke, trauma, encephalitis, brain metastasis and seizures

Design outcomes

Primary

Measure	Time frame
Difference in biomarker levels of neurodegenerative and synaptic biomarkers in asservated plasma between patients with delirium and without delirium.	—

Secondary

Measure	Time frame
Correlations of biomarker levels with demographic (e.g., age, sex) and diagnostic (e.g., laboratory values, cause of delirium) parameters.	—

Countries

Germany

Contacts

Public ContactJohannes Piel

Klinik für Neurologie, Haus DUniversitätsklinikum Schleswig-Holstein

johannes.piel@uksh.de0431-500-23900

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026