Metabolic, neuronal and immunological regulation of body weight

Metabolic, neuronal and immunological regulation of body weight - BTX

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027068

Enrollment

800

Registered

2023-01-30

Start date

2023-03-29

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Participants within all BMI-categories ( underweight up to obesity grade III) are eligible for participation in this basic research study.

Interventions

Group 1: Subjects within all body-mass-indices (BMI) categories (thinness up to obesity) who undergo interventions possibly affecting body weight regulation outside of this study. These interventions

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age equal to or above 18 years - Ability to understand and willingness to comply with study procedures, and to provide written informed consent - Fasted for at least eight hours (i.e. overnight) - General prerequisites for MR measurements (see “Selbstauskunft zu MRT für Probanden”) if applicable

Exclusion criteria

Exclusion criteria: - Severe dementia - Consuming illness with limited life expectancy - Poor knowledge of the German language - MRI contraindication (claustrophobia, large area tattoos, very poor eyesight) if applicable - Women: pregnancy, nursing - If the inclusion criteria are not applicable

Design outcomes

Primary

Measure	Time frame
The main objective of this study is to identify physiological mechanisms of weight regulation. Focus is, among others, on endocrinological, neurobiological, immunological, and psychosomatic mechanisms. Measurement time-points depend on the weight development of each participant, as measurements only take place on days of medically indicated assessments (for example, a participant undergoing bariatric surgery has medical appointments and hence measurements pre-surgery, 6 months after surgery, 12 months after surgery and then once per year). Measurements include neuropsychological assessments in combination with fMRI, blood value measurements, anthropometric measurements and further questionnaires.	—

Measure

Time frame

The main objective of this study is to identify physiological mechanisms of weight regulation. Focus is, among others, on endocrinological, neurobiological, immunological, and psychosomatic mechanisms. Measurement time-points depend on the weight development of each participant, as measurements only take place on days of medically indicated assessments (for example, a participant undergoing bariatric surgery has medical appointments and hence measurements pre-surgery, 6 months after surgery, 12 months after surgery and then once per year). Measurements include neuropsychological assessments in combination with fMRI, blood value measurements, anthropometric measurements and further questionnaires.

—

Secondary

Measure	Time frame
Not applicable, as this is a basic research study	—

Countries

Germany

Contacts

Public ContactRuth Hanßen

Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin

ruth.hanssen@uk-koeln.de+49 221 478 3783

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026