The influence of the gut microbiome on immunity mediated by COVID-19 vaccination

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027050

Enrollment

200

Registered

2021-11-11

Start date

2021-07-05

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

Group 1: People planning a COVID-19 vaccination with the vaccine from BioNTech/Pfizer: one stool and one blood sample before the vaccination, second stool sample 6 months after the vaccination and fou

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: plannend COVID-19 vaccination with BioNTech/Pfizer; Interval between first and second vaccination exactly 3 or 6 weeks (+/- 1 day); age from 18 years

Exclusion criteria

Exclusion criteria: antibiotic intake = 3 months before the start of the study; severe chronic illness; previous COVID-19 illness

Design outcomes

Primary

Measure	Time frame
influence of the gut microbiome on S1-antibodies & interferon-release assay	—

Secondary

Measure	Time frame
influence of the gut microbiome on timeline of immunity	—

Countries

Germany

Contacts

Public ContactCarolin von Kleist

Institut für Prävention und Tumorepidemiologie, Universitätsklinikum Freiburg

ipe.impfstudie@uniklinik-freiburg.de+49 761 270 77360

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026