Genetic Evaluation of Individuals with Features suggestive of a Cancer Predisposition Syndrome identified through the German Childhood Cancer Registry

Genetic Evaluation of Individuals with Features suggestive of a Cancer Predisposition Syndrome identified through the German Childhood Cancer Registry - CPS-GCCR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027022

Enrollment

1000

Registered

2023-01-23

Start date

2021-12-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer predisposition Z80 C79.9

Interventions

Group 1: Exome and / or, genome sequencing from blood or cheek mucosa samples after detailed human genetic counseling

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Surviving childhood cancer and 2. meet at least one of the following criteria: (a) subsequent neoplasia (s), (b) cancer diagnosis at age <18 years, (c) evidence of the presence of CPS due to the specific cancer disease or molecular / clinical abnormalities

Exclusion criteria

Exclusion criteria: cancer within the last year

Design outcomes

Primary

Measure	Time frame
Identification of cancer predisposition among this cohort via exam sequencing.	—

Countries

Germany

Contacts

Public ContactTanja Gerasimov

Zentrum für Kinderheilkunde und JugendmedizinKlinik für Pädiatrische Hämatologie und OnkologieOE 6780

KPS-DKKR@mh-hannover.de+49 (0)511 532 80801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026