Metabolic-cognitive control and long-term weight management in aging

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00027009

Enrollment

Registered

2021-11-03

Start date

2021-11-08

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity / adiposity E66

Interventions

Group 1: Within-subject design: Day 1: fMRI measurement with 160 IU intranasal placebo (0.27% m-cresol, 1.6% glycerol, 98.13% water) 8 puffs per nostril (1 x spray = 0.1 ml solution with 10 IU) Day

Eligibility

Sex/Gender

All

Age

55 Years to No maximum

Inclusion criteria

Inclusion criteria: - MRI-compatible - Medical information and signed declaration of consent

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
The primary outcome is to survey the metabolic-cognitive control of eating decisions, long-term weight management of elderly participants, and their insulin function. The following data will be collected: Screening: - Blood samples (insulin parameters: peripheral). - Anthropometric measurements. - Questionnaires. - Generation of the individual stimulus set. Day 1 & Day 2: - Blood samples (insulin parameters: peripheral) - Anthropometric measurements. - Administration: insulin / placebo. - fMRI o Neurobehavioral data. o Insulin parameters (centrally).	—

Measure

Time frame

The primary outcome is to survey the metabolic-cognitive control of eating decisions, long-term weight management of elderly participants, and their insulin function. The following data will be collected: Screening: - Blood samples (insulin parameters: peripheral). - Anthropometric measurements. - Questionnaires. - Generation of the individual stimulus set. Day 1 & Day 2: - Blood samples (insulin parameters: peripheral) - Anthropometric measurements. - Administration: insulin / placebo. - fMRI o Neurobehavioral data. o Insulin parameters (centrally).

—

Countries

Germany

Contacts

Public ContactVivien Breckwoldt

Institut für Systemische Neurowissenschaften - Universitätsklinikum Hamburg-Eppendorf

v.breckwoldt@uke.de040 / 7410 58203

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026