Identification of structural, functional, and metabolic brain alterations in Parkinson's disease and essential tremor using ultra-high-field MRI

Identification of structural, functional, and metabolic brain alterations in Parkinson's disease and essential tremor using ultra-high-field MRI - 7T PD ET MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00027008

Enrollment

Registered

2021-10-27

Start date

2021-11-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20.00 G25.0

Interventions

Group 1: Cohort 1: Patients with Parkinson's disease, Cohort 2: Patients with essential tremor, Cohort 3: healthy volunteers. All participants undergo ultra-high-field cranial MRI at 7 tesla und neuro

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ET and PD patients: Age>=18 years, diagnosis of either PD or ET made by a movement disorder specialist according to established criteria, sufficient mental abilty and German language skills to undertand the purpose and potential risks of the study, right-handedness Healthy volunteers: Age >= 18 years, sufficient mental abilty and German language skills to undertand the purpose and potential risks of the study, right-handedness

Exclusion criteria

Exclusion criteria: neurological diseases other than ET or PD with the exception of mild depression and REM sleep behavior disorder in PD patients, traumatic brain injury, pregnancy, breast feeding period, orthopedic conditions that wopuld prevent participant from lying flat in the MRI scanner, relevant medical condicitons such as severe heart disease or severe diabetes, drug- or alcohol addiction, contraindication for MRI (e.g. cardiac pacemaker, insuline pump, metal implants, severe claustrophobia etc.)

Design outcomes

Primary

Measure	Time frame
1) Gamma-aminobutyric acid concentration in the thalamus as assesed by sepctroscopy 2) Brain structure as assesed by anatomical imaging (MP2RAGE) 3) Brain activity during rest as assessed by EPIC based sequence 4) Brain water content as assessed by GRE sequence. All measures will be obtained via cranial MRI.	—

Countries

Germany

Contacts

Public ContactFlorian Holtbernd

Universitätsklinikum der RWTH AachenKlinik für Neurologie

fholtbernd@ukaachen.de00492418089600

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026