Exploring the modulation of cerebral blood flow and gamma-aminobutyric acid concentration induced by ethanol in essential tremor

Exploring the modulation of cerebral blood flow and gamma-aminobutyric acid concentration induced by ethanol in essential tremor - Tremor MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00026976

Enrollment

Registered

2021-10-25

Start date

2021-11-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G25.0

Interventions

Group 1: There are two groups (cohort 1: essential tremor pateitns, group 2: healthy volunteers). All participants are assessed by cranial MRI with and without oral intake of small amount of alcohol (

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age >=18 years - able to understand study purpose and risks in German language - for patients only: diagnosis of essential tremor made by a movement disorder specialist according to established criteria

Exclusion criteria

Exclusion criteria: - presence of other neurological or psychiatric conditions - drug or alcohol misuse (exceprion: cigarette smoking) - contraindications against MRI assessment (e.g. cardial pacemaker, joint replacements, tattoos etc.) - marked claustrophobia - contraindications against alcohol consumption - relevant medical conditions such as severe heart disease or metabolic disorders - pregnancy - breast feeding period - orthopedic disorders that would prevent participant from lying flat in the MRI scanner

Design outcomes

Primary

Measure	Time frame
Differences of cerebral blood flow, gamma-aminobutyric acid concentration, and brain activity during finger tapping as assessed by MRI in essential tremor patients compared to healthy controls.	—

Secondary

Measure	Time frame
Effect of alcohol on outcome measures listed under "primary endpoint" in both groups	—

Countries

Germany

Contacts

Public ContactFlorian Holtbernd

Universitätsklinikum der RWTH AachenKlinik für Neurologie

fholtbernd@ukaachen.de00492418089600

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026