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Mechanisms of self-generated positive and negative expectations on pain

Mechanisms of self-generated positive and negative expectations on pain - A03_C

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00026966
Enrollment
40
Registered
2022-01-03
Start date
2021-10-22
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain and pain treatment

Interventions

Group 1: Participants will be instructed to build up an expectation of a weakly painful stimulus (positive expectation condition). 30 trials per measurement. In pseudorandomized order with arms 1 and

Sponsors

Universitätsklinikum Hamburg-Eppendorf
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Healthy adults with normal or corrected-to-normal vision, right-handed

Exclusion criteria

Exclusion criteria: - red-green deficiency - chronic or acute disease or pain - neurological or psychiatric disorders - pregnancy - regular medication intake (except contraceptive), recent use of psychotropic or analgesic substances - use of illegal drugs - smoking - participation in any medication-associated experimental study in the last 6 months

Design outcomes

Primary

MeasureTime frame
We will test if cued self-generated expectations affect pain processing. Our main aim is to assess time-frequency (EEG) neural characteristics of self-generated positive and negative expectations on pain in the expectation phase directly prior to the application of painful stimuli.

Secondary

MeasureTime frame
In addition, we will examine neural processes after the cue presentation and during the application of the pain stimuli.

Countries

Germany

Contacts

Public ContactChristoph;Maren-Isabel Wittkamp;Wolf

Universitätsklinikum Hamburg-Eppendorf, Institut für systemische Neurowissenschaften;Institut für systemische NeurowissenschaftenUniversitätsklinikum Hamburg-Eppendorf

c.wittkamp@uke.de;ma.wolf@uke.de+49 (0) 40 7410 - 54260;+49 (0) 40 7410 - 59902

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026