Salivary Flow Rate and pH during Toothbrushing

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026949

Enrollment

Registered

2022-03-10

Start date

2021-10-21

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Basic research/Physiological Study - no health conditions under consideration

Interventions

Group 1: Non-Interventional basic research/physiological study without group separation. A total of 4 session per volunteer: 1. Stimulated and Unstimulated salivary flow is determined. The saliva col

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy adult volunteers, 15 males and 15 females. The minimum age requirement has been set at 18 = years of age.

Exclusion criteria

Exclusion criteria: - Persons with salivation rates deviating from predetermined norm values - Persons who take medication with known effects on salivary flow or intraoral pH value - Women who are pregnant - Persons participating in another clinical trial at the same time - Persons with known allergies or intolerances towards an ingredient in the test toothpastes - Persons with less than 20 teeth - Persons wearing any active orthodontic appliances at the time of the study (with the exception of a dental retainer) - Persons with any open intraoral wounds - Persons with dental appointments (dentist or dental hygienist) scheduled less than one day from study trial appointments (Procedures performed during dental appointments may cause intraoral bleeding (for example after periodontal probing), influence salivary flow or intraoral pH (for example through the use of anaesthetics or etching agents)). - Persons unable to give an informed consent or to follow protocol requirements and procedures

Design outcomes

Primary

Measure	Time frame
The primary objective of this research project is to determine pH values of oral fluids and assess the salivary flow rate and subsequent dilution of toothpaste during toothbrushing with toothpastes of various pH values.	—

Countries

Switzerland

Contacts

Public ContactAnina Pulfer

Zentrum für Zahnmedizin, Universität Zürich, Klinik für Zahnerhaltung und Präventivzahnmedizin

anina.pulfer@zzm.uzh.ch+41 44 634 33 16

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026