K65 K74.6
Conditions
Interventions
Group 1: patients, who develop a nosocomial SBP:
patients are recruited and samples collected after exclusion of SBP at initial paracentesis. In case of SBP in a later paracentesis samples are collec
Sponsors
Klinik und Poliklinik für Innere Medizin II Klinikum rechts der Isar der TU München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - patients with liver cirrhosis (confirmed by ultrasound, CT or histology) and ascites - indication for paracentesis
Exclusion criteria
Exclusion criteria: - age <18 years - unable to give informed consent - pregnancy - SBP at admission - antibiosis within 14 days prior to recruitment - status post liver transplantation - pharmacological or acquired (e.g. HIV) immune deficiency - surgery within 6 months prior to recruitment - status post colectomy - active neoplastic disease - secondary peritonitis - patients on ICU - cirrhose cardiac - cleansing for colonoscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Analysis of the gastrointestinal microbiome in patients with SBP: • Description of the microbiome in those patients in specimen of the oral cavity, the duodenum, the ascites and the stool • Comparison of the microbiome of patients with and without SBP | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) Analysis of oral overgrowth of the microbiome in the small intestine by typical oral bacteria by comparison of duodenal and faecal with oral (saliva) samples. 3) Changes in the microbiome as risk factor of SBP. • Multivariate regression analysis of SBP risk factors • Association of pathogens in ascites / ascitic microbiome with changes in the intestinal microbiome | — |
Countries
Germany
Contacts
Public ContactSebastian Rasch
Klinik und Poliklinik für Innere Medizin II Klinikum rechts der Isar der TU München
Outcome results
None listed