Skip to content

Embryo transfer with intrauterine application of human chorionic gonadotropin (hCG) to improve implantation- and pregnancy rates - a randomized controlled study

Embryo transfer with intrauterine application of human chorionic gonadotropin (hCG) to improve implantation- and pregnancy rates - a randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00026832
Enrollment
1504
Registered
2021-10-19
Start date
2013-09-09
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N46 N97

Interventions

Group 1: Intrauterine application of 500 IU hCG (Pregnyl, ORGANON, Netherlands) dissolved in 40 µl embryo culture medium G-2™ PLUS (Vitrolife, Sweden) on day 3 after ovum pick up. Group 2: Intrauterin

Sponsors

IVF-Zentren Prof. Zech, Pilsen
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 43 Years

Inclusion criteria

Inclusion criteria: Included were all fresh blastocyst transfers on day 5 after ovum pick up

Exclusion criteria

Exclusion criteria: Female age =44 years (no age limit for male partner) Known chromosomal aberration either by female or by male partner IVF-cycles with preimplantation genetic analysis IVF-cycles with use of donor oocytes Patients with recurrent implantation failure (=3 negative IVF-cycles)

Design outcomes

Primary

MeasureTime frame
Implantation rate (number implanted embryos/ number transfered embryos; pregnancy rate: number positive pregnancy tests (beta-hCG) / number embryo transfers, clinical pregnancy rate: number of verified pregnancy tests by fetal heart beat / number embryo transfers; miscarriage rates: miscarriages/ number of embryo transfers; Live birth rates: number of deliveries / embryo transfers

Secondary

MeasureTime frame
Miscarriage rate after foetal heartbeat (miscarriages /verfied ckinical pregnancies) Live birth rate (Live birth / embryos transferred)

Countries

Czechia

Contacts

Public ContactLibor Hradecký

IVF-Zentren Prof. Zech, Pilsen

office.pilsen@next-fertility.cz+420 377 279 352

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026