C43
Conditions
Interventions
Group 1: Optoacoustic examination of the lymph nodes is performed as part of the regular presentations (initial examination, sonographic follow-up). The further follow-up observations within the frame
Sponsors
Uniklinik Essen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with a history of melanoma who require regular lymph node ultrasonography according to the guidelines and who currently show a sonographic suspicion of lymph node metastasis. Furthermore, patients must have received an mRNA-based Covid-19 vaccination within the last 8 weeks. Patients with the presence of melanoma disease who require regular lymph node sonography in accordance with national guidelines and have sonographically unremarkable lymph nodes. Furthermore, patients must have received an mRNA-based Covid-19 vaccination within the last 8 weeks.
Exclusion criteria
Exclusion criteria: Insufficient ability to communicate in the German language or lack of understanding of the German language (Functional) illiteracy Lacking or missing capacity of the patient to give consent
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Correlation of detected differences in oxygenation and melanin content to other patient characteristics such as age, gender, tumor characteristics (tumor stage, mutation status of the tumor, histological characteristics such as PD-L1 expression of the tumor). | — |
Primary
| Measure | Time frame |
|---|---|
| Significant differences in ratios of oxy- /deoxyhemoglobin and melanin content in patients with melanoma lymph node metastases and in patients with reactive lymph node lesions after Covid-19 vaccination. | — |
Countries
Germany
Contacts
Public ContactJan-Malte Placke
Klinik und Poliklinik für Dermatologie, Venerologie und AllergologieUniversitätsklinikum Essen
Outcome results
None listed