Early degeneration of the bioprothesis after catheter-assisted aortic valve implantation (TAVI)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026795

Enrollment

105

Registered

2022-02-14

Start date

2022-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I35.0

Interventions

Group 1: pre- and post-interventional analysis of the inflammatory parameters and microbioma analysis CT-scan and transthoracic echocardiography 3 months after procedure

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients with symptomatic, severe Aortic stenosis and indication for TF-TAVI-procedure patients agreement

Exclusion criteria

Exclusion criteria: excluding criteria for TAVI-procedure inflammatory bowel diseases pre-existing coagulopathy pre-existing autoimmune disease chronic diseases of the hematopoietic system serum-creatinine level >2,0mg/dl (except patients with chronic kidney disease under dialysis) hyperthyroidism

Design outcomes

Primary

Measure	Time frame
identification of pro-cogulatory and pro-inflammatory processes that lead to an early valve degeneration	—

Secondary

Measure	Time frame
Changes of the microbioma as an expression of the remodeling of the intestinal biotope	—

Countries

Germany

Contacts

Public ContactPolykarpos C. Patsalis

Med. Klinik II - Kardiologie und AngiologieBerufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH

polykarpos.patsalis@bergmannsheil.de0234-3026050

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026