U07.1 U09.9
Conditions
Interventions
Group 1: Strength and endurance training (2-3x per week for 4 weeks)
Group 2: Observation
Sponsors
Klinik und Poliklinik für Kardiologie am Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with persistent fatigue after cured COVID-19 disease min. 6 weeks, MFI > 50 min 4/5 areas affected - Post-Covid Functional Scale ± 2 - Normal LVEF - Nt-pro-BNP, troponin T in normal range - FEV1 and FVC within normal range
Exclusion criteria
Exclusion criteria: - Known underlying pulmonary or cardiac disease defined as heart failure with preserved or reduced pump function, myocarditis, known coronary artery disease, obstructive restrictive lung disease. - COVID-19 conditional cardiovascular complication e.g. pulmonary embolism, pulmonary fibrosis, myocardial infarction, myocarditis. - Lack of consent - Pregnancy - Age<18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Subjective improvement in perceived fatigue according to MFI-20 in at least 2 of 5 categories at follow-up (1st/3rd/6th month) | — |
Secondary
| Measure | Time frame |
|---|---|
| - VO2 max., O2 pulse - Improvement in quality of life according to McGill Quality of Life Questionnaire (MQOL) - Improvement in Post-Covid-Functional-Scale - 1-RM (Repetition maximum) - Strength performance - Leisure time activity (Physical activity Assessment) - Cardiac enzymes, CBC, NLRP3 inflammasome, inflammatory parameters 1st month follow-up, questionnaires also 3rd month and 6th month | — |
Countries
Germany
Contacts
Public ContactSven Fikenzer
Universitätsklinikum Leipzig
Outcome results
None listed