Effects of hypoxia on A1 adenosine receptor availability in the human brain

Effects of hypoxia on A1 adenosine receptor availability in the human brain - AdenOx

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00026685

Enrollment

Registered

2021-10-04

Start date

2021-12-07

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of hypoxia on availability of A1 adenosine receptors

Interventions

Group 1: Participants breath a gas mixture with normal oxygen concentration (21%) from a reservoire as control condition for fMRI-PET and cognitive performance data acquisition. Group 2: Participants

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - age: 18 years or older - each sex - written informed consent

Exclusion criteria

Exclusion criteria: BMI > 35 - no German fluency - medication with impact on the examined data - anticoagulation therapy or coagulation disorder - chronic diseases: e.g. neurological, cardio-pulmonal, endocrine, renale, hepatic, psychiatric or autoimmune diseases - past acute cardio-vascular events (stroke, TIA) - occupational radiation exposure - substance abuse - electrical implants for stimulation or therapy - metallic devices at or in the body (e.g. surgical screws, implants or material for osteosynthesis) which are not compatible with MRI - fixed braces or retainers - tatoos in the examined area of the body - intensive grinding at metallic objects in the past month - pain e.g. back pain - pregnancy - nursing - person with no or limited legal capacity or person in official custody - each additional condition which deems the participant unsuitable to the MD in charge (claustrophobia, non-compliance) - copper intrauterinepessar - hormonal intrauterinepessar if not compatible with MRI - smokers

Design outcomes

Primary

Measure	Time frame
Change in A1 adenosine receptor availability (measured as distribution volume with PET) under hypoxia in comparison to normoxia in the frontal cortex.	—

Secondary

Measure	Time frame
Change of cognitive performance (attention measured with a psychomotor vigilance task (PVT) under hypoxia in comparison to normoxia. Change in cerebral blood flow (measured with arterial spin labelling in the MRI) under hypoxia in comparison to normoxia.	—

Countries

Germany

Contacts

Public ContactEva-Maria Elmenhorst

Deutsches Zentrum für Luft- und Raumfahrt

eva-maria.elmenhorst@dlr.de02203 6014735

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026