Z94.0
Conditions
Interventions
Group 1: A multimodal monitoring for the detection of medical non-adherence: Torque Teno virus quantification in plasma, tacrolimus trough level variance, self-reports by BAASIS© questionnaires, elect
Sponsors
Universitätsklinik Wien
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Informed and written voluntariy consent to participate to this study - Sufficient physical and mental ability for participation - Transplanted at the Vienna General Hospital (Medical University of Vienna) - Continued follow-up care at the department of nephrology and dialysis, devision of internal medicine III, Medical University of Vienna
Exclusion criteria
Exclusion criteria: - Withdrawal of consent - Significant language barrier, which impeded the study participation - Early allograft loss or death before first visit at the out-patient clinic after transplantation - Follow-up care at a peripheral ambualnce direct after dismission from the ward
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biopsy proven graft rejection. When? - during the whole study period (from day of transplant, up to 4 years post-transplant) How?: Transplant biopsy analyzed by blinded nephropathologist | — |
Secondary
| Measure | Time frame |
|---|---|
| Death, transplant loss, evaluation of single compartments in the transplant biopsy according to BANFF single scores, de novo donor-specific antibodies (DSA), the estimated glomerular filtration rate (according to current CKD-EPI formula), urinary protein-creatinine ratio, WHOQL-100, urinary chemokines (CXCL 9 and 10); compound endpoint including biopsy proven rejection (primary end-point), de novo DSA and urinary chemokines | — |
Countries
Austria
Contacts
Public ContactFrederik Haupenthal
Universitätsklinik für Innere Medizin III., Abt. für Nephrologie und Dialyse
Outcome results
None listed