A18
Conditions
Interventions
Group 1: Individuals with presumed TB disease undergo abdominal and thoracic ultrasound examination and results will be correlated with the reference standard (TB diagnosed?)
Sponsors
Deutsches Zentrum für Infektionsforschung
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - patients aged 18 years or older - presenting with: clinical constellation compatible with pulmonary TB (PTB) and/or extra-pulmonary (EPTB) - AND TB presumed to be highly likely differential diagnosis due to clinical, radiological, laboratory information - AND at least one of the symptoms below suggestive of TB (as defined by WHO): o Current cough of 2 weeks or of any duration in PLHIV o Night sweats o Fever o Weight loss - Willingness to have a study follow-up visit at 2-3 months after enrolment (e.g. not planning to relocate). - if considered for follow-up study: willingness to have follow-up visits at 1, 2, 4, 6 months of anti-TB treatment
Exclusion criteria
Exclusion criteria: - no consent given - confirmed diagnosis of TB by sample >14 days ago (by sputum microscopy, culture, PCR) - on anti-tuberculous (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol, Quinolones) for more than 24 hours - on anti-tuberculous treatment (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol, Quinolones) in past 60 days - on preventive therapy for TB infection within the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnostic accuracy of single ultrasound findings as compared to the reference standard | — |
Secondary
| Measure | Time frame |
|---|---|
| evolution of ultrasound findings under anti-TB therapy | — |
Countries
Germany, India
Contacts
Public ContactClaudia Denkinger
Sektion klinische Tropenmedizin, UK Heidelberg
Outcome results
None listed