Complex regional pain syndrome and primary headache: coincidence or causality? - From a neurophysiological point of view

Complex regional pain syndrome and primary headache: coincidence or causality? - From a neurophysiological point of view - CRPSM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026611

Enrollment

Registered

2021-09-30

Start date

2021-10-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G90.7 G43

Interventions

Group 1: CRPS patients anamnesis (history of disease, clinical assessment). planned examination: cMRI (anatomical sequences), recording of blink reflex and transcranial magnetic stimulation (combined

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Arm 1: - Diagnosis CRPS Arm 2: - Diagnosis: episodic migraine Arm 3 - healthy controls

Exclusion criteria

Exclusion criteria: - mental illness (mild depression excluded) - MRI contraindication (pacemaker, medication pumps, claustrophobia) - CGRP antibodies for migraine prophylaxis - Prophylactic Botox therapy (migraine prophylaxis) - Epilepsy

Design outcomes

Primary

Measure	Time frame
Combined endpoint of R2 area and habituation of the nociceptive blink reflex.	—

Secondary

Measure	Time frame
Medical history - Demography and social anamnesis - Medical history - Medication history - Family history II) Electrophysiology - Blink reflex - Nociceptive evoked potentials - Somatosensory evoked potentials (SSEP) - Motor evoked potentials (MEP) - conditioned with peripheral somatosensitive Stimulation - conditioned by activation - Connectivity in the electroencephalogram (EEG) III) Imaging - structural MRI (volumetry, tractrography)	—

Measure

Time frame

Medical history - Demography and social anamnesis - Medical history - Medication history - Family history II) Electrophysiology - Blink reflex - Nociceptive evoked potentials - Somatosensory evoked potentials (SSEP) - Motor evoked potentials (MEP) - conditioned with peripheral somatosensitive Stimulation - conditioned by activation - Connectivity in the electroencephalogram (EEG) III) Imaging - structural MRI (volumetry, tractrography)

—

Countries

Germany

Contacts

Public ContactSebastian Strauss

Klinik und Poliklinik für Neurologie

Sebastian.Strauss@med.uni-greifswald.de03834 86-6815

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026