Optimisation of DBS Therapy for Parkinson’s Disease Patients using Electrophysiological Biomarkers

Optimisation of DBS Therapy for Parkinson’s Disease Patients using Electrophysiological Biomarkers - OPEL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026257

Enrollment

Registered

2021-09-20

Start date

2021-12-14

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20.11

Interventions

Group 1: Patients suffering from Morbus Parkinson undergoing bilateral deep brain stimulation therapy of the nucleus subthalamicus and implanted Medtronic Percept Impulsegenerator

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: • Patients with implanted PerceptTM Neurostimulator • Patients with IPS • Patients with bilaterally implanted lead electrodes in the STN or VIM • Declaration of consent • Patient age must be between 18 and 80 years

Exclusion criteria

Exclusion criteria: • Patients with severe cognitive or psychiatric deficits • Patients that are non-cooperative or non-competent

Design outcomes

Primary

Measure	Time frame
Differences in ß-activity between patient’s motor off-state and on-state according to UPDRS-III	—

Secondary

Measure	Time frame
ß-activity in dependence of medication intake	—

Countries

Germany

Contacts

Public ContactMichael Barbe

Universitätsklinik Köln, Klinik und Poliklinik für Neurologie

michael.barbe@uk-koeln.de+492214787494

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026