Catecholamines in preterm infants - which role do they play in blood glucose regulation in the first weeks of life?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026230

Enrollment

Registered

2021-10-04

Start date

2021-11-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E16.1 P70.4

Interventions

Group 1: Premature infants < 1500 g or < 32 + 0 weeks of gestation will be included. Arterial cord blood will be obtained after cord clamping to determine catecholamines, catecholamine-metabolites and

Eligibility

Sex/Gender

All

Age

0 Days to 3 Days

Inclusion criteria

Inclusion criteria: Premature infants < 1500 g or < 32+0 weeks of gestation and consent of both parents.

Exclusion criteria

Exclusion criteria: Lack of parental consent.

Design outcomes

Primary

Measure	Time frame
1. To evaluate if catecholamine concentrations/their metabolites correlate with severity of illness over time, and if there is a specific decrease of catecholamine levels after clinical stabilization. 2. To evaluate if there is a correlation between catecholamine levels in arterial cord blood and urine with glycemia in preterm infants during the first weeks of life.	—

Secondary

Measure	Time frame
To evaluate if 1. infections, intubation, ventilation, apneas, bradycardias, medications, kangaroo care, etc. have an effect on urinary catecholamine concentrations. 2. one or more catecholamines/metabolites in arterial cord blood or urine serve as a screening parameter to predict the risk for hypoglycemia and transient hyperinsulinism in preterm infants. 3. the levels of catecholamines correlate with the levels of C-peptide in urine. 4. the levels of catecholamines/metabolites in arterial cord blood and urine are weight dependent. 5. the duration of prenatal risk factor exposure correlates with the levels of catecholamines and with the postnatal blood glucose levels. 6. other factors like maternal BMI, maternal medication, smoking, alcohol and other drugs etc. have an influence on the catecholamine levels and/or postnatal blood glucose levels in preterm infants. 7. the levels of catecholamines correlate with the need for oral glucose gel, intravenous glucose, subcutaneous glucagon, diazoxide and duration of hospitalization. 8. to establish reference ranges for umbilical artery catecholamines in preterm infants.	—

Measure

Time frame

To evaluate if 1. infections, intubation, ventilation, apneas, bradycardias, medications, kangaroo care, etc. have an effect on urinary catecholamine concentrations. 2. one or more catecholamines/metabolites in arterial cord blood or urine serve as a screening parameter to predict the risk for hypoglycemia and transient hyperinsulinism in preterm infants. 3. the levels of catecholamines correlate with the levels of C-peptide in urine. 4. the levels of catecholamines/metabolites in arterial cord blood and urine are weight dependent. 5. the duration of prenatal risk factor exposure correlates with the levels of catecholamines and with the postnatal blood glucose levels. 6. other factors like maternal BMI, maternal medication, smoking, alcohol and other drugs etc. have an influence on the catecholamine levels and/or postnatal blood glucose levels in preterm infants. 7. the levels of catecholamines correlate with the need for oral glucose gel, intravenous glucose, subcutaneous glucagon, diazoxide and duration of hospitalization. 8. to establish reference ranges for umbilical artery catecholamines in preterm infants.

—

Countries

Germany

Contacts

Public ContactHenrike Hörmann

Universitätsklinikum Düsseldorf, Klinik für Allgemeine Pädiatrie, Neonatologie und Kinderkardiologie

henrike.hoermann@med.uni-duesseldorf.de0049-211-81-17687

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026