Alcohol Use Disorder (DSM-5)
Conditions
Interventions
Group 1: Crossover design, randomized, double-blind:
Participants take part in a cue exposure with their favorite alcoholic beverage. Alcohol craving will be assessed with the Alcohol Urge Questionnai
Sponsors
Zentralinstitut für Seelische Gesundheit
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 65 years; ability to give fully informed consent and to undergo functional magnetic resonance imaging; written informed consent; diagnosis of alcohol use disorder according to DSM-5 (min. 2 AUD criteria).
Exclusion criteria
Exclusion criteria: Pregnancy or lactation; presence of severe heart disease or long QT syndrome; participants 65 years of age; psychosis or other severe psychiatric disorder; severe internistic and neurological comorbidities; use of psychotropic medication other than antidepressants from the group of serotonin reuptake inhibitors (SSRI) or mirtazapine and of pipamperone; Current drug abuse of amphetamines, opiates, benzodiazepines, and cocaine (urine drug screening); Contraindication to functional magnetic resonance imaging.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cue-reactivity (fMRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Alcohol Urge Questionnaire (repeated measurement; sum scores) depressive symptoms (BDI-II sum score) anxiety (STAI sum score) perceived stress (Perceived Stress Scale sum score) personality (NEO-FFI sum score, only compared between subjects) biomaterials - oxytocin plasma level - cortisol level (saliva) - inflammation markers - appetite- and volume markers (leptine, ghrelin) | — |
Countries
Germany
Contacts
Public ContactSina Zimmermann
Zentralinstitut für seelische Gesundheit
Outcome results
None listed