One-step autologous cartilage regeneration versus two-step autologous chondrocyte implantation: A randomized controlled trial evaluating clinical, radiological and patient related outcomes

One-step autologous cartilage regeneration versus two-step autologous chondrocyte implantation: A randomized controlled trial evaluating clinical, radiological and patient related outcomes - MCI vs. ACT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00026196

Enrollment

100

Registered

2021-09-07

Start date

2021-09-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M94.86

Interventions

Group 1: Surgical treatment with MCI Group 2: Surgical treatment with ACI

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Symptomatic cartilage defect of the knee (size 2.5-6 cm), Focal defect grade 3 or 4 according to the International Cartilage Repair Society (ICRS)

Exclusion criteria

Exclusion criteria: Systemic disease (Rheumatic disease, Diabetes etc.), Previous surgeries at the cartilage, menisci or ligaments of the knee, History of fractures or osteotomies of the lower extremities

Design outcomes

Primary

Measure	Time frame
Knee Injury and Osteoarthritis Outcome Score (KOOS; questionnaire) after 24 months	—

Secondary

Measure	Time frame
KOOS after 6 and 12 months, IKDC-Score after 6, 12 and 24 months, Tegner activity score after 6, 12 and 24 months, quantitative and qualitative MRI evaluation (MOCART-Score) after 12 months	—

Countries

Germany

Contacts

Public ContactJulian Mehl

Abteilung und Poliklinik für Sportorthopädie, Klinikum rechts der Isar

julian.mehl@mri.tum.de089/41407840

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026