Influence of hemodilution on the microcirculation during cardiac surgery with heart-lung machine

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026185

Enrollment

Registered

2021-10-15

Start date

2021-11-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microcirculation

Interventions

Group 1: Non-invasive measurement of the sublingual microcirculation using a MicroScan® microscope measures the influence of haemodilution on the microcirculation during cardiac surgery with heart-lun

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age at least 18 years or older Cardiac surgery with heart-lung-maschine Surgery in normothermia Signed consent form

Exclusion criteria

Exclusion criteria: No access to the sublingual mucosa, for example due to previous injuries or surgery in this area Emergency surgery Patients with endocarditis Pregnancy Re-operations Known preoperative renal insufficiency or Creatinine level >1.3 mg/dl Multimorbid patients Preoperative anemia Procedures with minimized heart-lung machine No informed consent or withdrawal of signed consent

Design outcomes

Primary

Measure	Time frame
In the statistical evaluation, both groups will be compared with regard to the following parameters obtained by measuring the sublingual microcirculation: - Total vessel density - Perfused vessel density - Functional capillary density - Microvascular flow index - Erythrocyte velocity Sublingual microcirculation is measured before extracorporal circulation, after induction of cardiac arrest and after aortic cross clamping. The null hypothesis of the study is: Haemodilution during cardiac surgery with the aid of extracorporal circulation has no effect on the sublingual microcirculation.	—

Measure

Time frame

In the statistical evaluation, both groups will be compared with regard to the following parameters obtained by measuring the sublingual microcirculation: - Total vessel density - Perfused vessel density - Functional capillary density - Microvascular flow index - Erythrocyte velocity Sublingual microcirculation is measured before extracorporal circulation, after induction of cardiac arrest and after aortic cross clamping. The null hypothesis of the study is: Haemodilution during cardiac surgery with the aid of extracorporal circulation has no effect on the sublingual microcirculation.

—

Secondary

Measure	Time frame
Correlation between cardiac output, mean arterial pressure, indexed oxygen supply during extracorporeal circulation and sublingual microcirculation. Furthermore, a possible correlation between acute renal failure up to 48 hours postoperatively according to Kidney Disease: Improve Global Outcome criteria and the sublingual microcirculation during extracorporeal circulationwill be investigated.	—

Countries

Germany

Contacts

Public ContactMagdalena Rufa

Robert-Bosch-Krankenhaus

magdalena.rufa@rbk.de0711 8101 5273

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026