Pain and Pain Treatment
Conditions
Interventions
Group 1: Using a sham Brain-Computer-Interface a placebo will be induced (expectation towards a brain state of low pain susceptibility).
30 trials per measurement. In pseudorandomized order with Arm
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Healthy adults with normal or corrected-to-normal vision, right-handed
Exclusion criteria
Exclusion criteria: - any contraindications for MRI measurement (metal implants, non-removable piercings, heart pacemaker, tattoos close to the head, known claustrophobia) - red-green deficiency - chronic or acute disease or pain - neurological or psychiatric disorders - pregnancy - regular medication intake (except contraceptive), recent use of psychotropic or analgesic substances - use of illegal drugs - consumption of caffeine 2 hours before MRI testing and consumption of alcohol on the day of testing and the previous day - smoking - participation in any medication-associated experimental study in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our aim is to assess time-frequency (EEG)neural characteristics of positive and negative expectations on pain in the expectation phase prior to the application of painful stimuli and to explore the stability of placbeo and nocebo effects. | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, we will examine the neural processes after the cue presentation and after the application of the pain stimuli. | — |
Countries
Germany
Contacts
Public ContactMaren-Isabel;Christoph Wolf;Wittkamp
Institut für systemische NeurowissenschaftenUniversitätsklinikum Hamburg-Eppendorf;Universitätsklinikum Hamburg-Eppendorf, Institut für systemische Neurowissenschaften
Outcome results
None listed