Trancriptome patterns in dermal schwann cells in neuropathic itch and pain

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026173

Enrollment

570

Registered

2021-08-27

Start date

2022-02-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G62 L29.9

Interventions

Group 1: Peripheral neuropathy (PNP): Patients with different PNP aetiologies: multimodal investigation Group 2: Brachioradial pruritus (BRP): patients with brachioradial pruritus (comparison group):

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: For screening: Diagnosis of peripheral neuropathy For participation in the other parts of the study: Diagnosis of peripheral neuropathy OR diagnosis of brachioradial pruritus OR healthy control subject. Additional inclusion criterion for peripheral neuropathy: In the diary over one week, moderate pain = NRS 5 and, pruritus = 1 OR moderate pruritus = 5, pain = 1.

Exclusion criteria

Exclusion criteria: Other serious illness that would falsify the examination results or make participation difficult, known wound healing disorders or anticoagulation (due to skin biopsy).

Design outcomes

Primary

Measure	Time frame
Expression of IF144L in the skin	—

Secondary

Measure	Time frame
Itch severity under C-fibre stimulation	—

Countries

Germany

Contacts

Public ContactClaudia Sommer

Universitätsklinikum Würzburg Neurologische Klinik

sommer@uni-wuerzburg.de0931/2010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026