L20.8
Conditions
Interventions
Group 1: Atopical Subjects:
We first want to evaluate the intensity of different peripheral itch-related stimuli in atopic individuals including wool fibres (mechano-sensitive itch), cowhage spicules
Sponsors
Universitätshautklinik
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - The patient can give the written informed consent prior to any study-related examinations or procedures. - The patient is = 18 years old at the time of signing the consent form. - Confirmed diagnosis of moderate to severe atopic dermatitis diagnosed by a senior physician and the presence of symptoms of moderate to severe atopic dermatitis as clinically assessed by the physician at the time of admission. - No current treatment with immunosuppressive medication or antihistamines. - The patient must be suitable for MRI examination (e.g., no heart pacemaker or metal implants). - The patient is treated according to local and national guidelines. The physician's decision regarding the above treatment must have been made before and independently of enrollment in the study. - Treatment will be prescribed in accordance with the appropriate product information and local as well as national licensing and reimbursement guidelines. - The patient can understand and communicate with the investigator and to meet the requirements of the study.
Exclusion criteria
Exclusion criteria: no
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypothesis that systemic IL-4/IL-13 receptor blockade critically modulates brain activity and central nervous itch perception. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcomes plannend because he current study is a pilot study. Depending on our findings, we will plan a subsequent study with a higher number of patients. | — |
Countries
Germany
Contacts
Public ContactBritta Nitschke
Universitätshautklinik
Outcome results
None listed