Placebo effects T78.4
Conditions
Interventions
Group 1: Conditioned group: Receives an anti-histaminergic drug in combination with a distinctly tasting drink during the acquisition phase
receives only drink and placebo during the evocation phase
Group 2: Context control-group: Acquisition phase as in conditioned group (arm 1), but only receives water and placebo during the evocation p
there is no blinding with regard to the placebo application, but participants are informed about the potential positive effects of placebo treatments
Sponsors
Universitätsklinikum Essen (AöR), Klinik für Dermatologie, Venerologie und Allergologie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Healthy participants aged >18 and <65 years, who consent to study participation in writing
Exclusion criteria
Exclusion criteria: - Pregnant or breast-feeding women - Insufficient communication skills in the German language, dementia or functional analphabetism - Lack of capacity or will to consent to the study - Regular intake of anti-histaminergic medication - Seasonal rhinoconjunctivits during the pollen season - Skin diseases on the forearms that permit from evaluating the prick-test - Known allergies against components of Cetirizin and/or the drink used for the conditioning procedure - Known mastocytosis - Lactose intolerance (medication contains lactose)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of erythema size (in cm) and wheal size (in mm) at baseline and after three and five days of the experimental manipulation | — |
Secondary
| Measure | Time frame |
|---|---|
| Perceived itch on a numeric rating scale (0-100) at baseline and after three and five days of the experimental manipulation | — |
Countries
Germany
Contacts
Public ContactWiebke Sondermann
Universitätsklinikum Essen (AöR), Klinik für Dermatologie, Venerologie und Allergologie
Outcome results
None listed