E26.0
Conditions
Interventions
Group 1: Patients will be given intensive dietary advice to achieve a moderate reduction of dietary salt intake and are followed for about 12 weeks
Sponsors
Medizinische Klinik und Poliklinik IV, LMU Klinikum München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - diagnosis of primary aldosteronism with specific treatment using mineralocorticoid receptor antagonists - written informed consent
Exclusion criteria
Exclusion criteria: - severe comobidities - age below 18 years - intended lifestyle changes (e.g. sports) - pregnancy, or planned pragnancy within the next 6 months - surgery or planned surgery within the next 6 months - cardiac infarction or stroke within the last 6 months - recently performed radiation or chemotherapy - alcohol abuse or illegal drug use within the last 6 months - active smoking status - severe dietary restrictions/allergies - other secondary causes of hypertension - no possiibility for informent consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline systolic blood pressure at the end of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in 1) Surrogate markers of cardiovaskular risk (e.g. Proeinuria, arterial stiffness) 2) Body composition 3) Mental well-being 4) Taste perception for sodium chloride 5) Hormonell status(e.g. aldosterone, renin) 6) Gut microbiome and markers of inflammation/autoimmunicity 7) 24-hour urinary sodium and cortisol excretion | — |
Countries
Germany
Contacts
Public ContactChristian Adolf
Medizinische Klinik und Poliklinik IV, LMU Klinikum München
Outcome results
None listed