Humoral and cellular immune response of the adaptive immune system after vaccination or natural COVID infection

Humoral and cellular immune response of the adaptive immune system after vaccination or natural COVID infection - COV-ADAPT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00026029

Enrollment

400

Registered

2021-08-30

Start date

2021-05-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune response following vaccination

Interventions

Group 1: Before and after boost in heterologous ChAdOx (Astra Zeneca) vaccination, a total of three blood draws are performed (1st blood draw between prime and boost vaccination, 2nd blood draw up to

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: - Age between 18 and 75 years - Ability to give consent is given - Basic willingness to be vaccinated - Basic willingness to have blood drawn at 3 points in time - Employed at the University Medical Center Göttingen

Exclusion criteria

Exclusion criteria: - Acute COVID-19 infection - domestic quarantine

Design outcomes

Primary

Measure	Time frame
Antibody titer and T-cell response 3-6 months after the 2nd vaccination and 4-6 months after the 3 vaccination.	—

Secondary

Measure	Time frame
Development of the AK titre and the T cell response over time and the correlation between the two values	—

Countries

Germany

Contacts

Public ContactMoritz Hollstein

Universitätsmedizin Göttingen

moritz.hollstein@med.uni-goettingen.de0551-39066401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026