T07
Conditions
Interventions
Group 1: Patients with ISS >9 without severe injuries of internal organs: collection of 10 ml whole blood samples at fixed time points (day of trauma, at 1st hour, at 8th hour, after 24th hours, after
Sponsors
Bundeswehrzentralkrankenhaus Koblenz
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Trauma patient with ISS >9
Exclusion criteria
Exclusion criteria: No declaration of consent, pregnancy, participants unter 18 years old, doubts about the patient's ability to consent or signs of dementia, as well as incomplete blood collection series. In addition, patients with acute or chronic inflammation, e.g., autoimmune hepatitis, but also genetic diseases, cholestatic diseases, and patients with co-infection, such as HCV and HBV or HCV and HIV, are excluded, as these have been shown to alter the fibrolytic EV profile.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate a) whether the severity of trauma can be assessed by EV signature (correlation with ISS) and b) whether polytrauma patients with internal organ damage can be differentiated from polytrauma patients without internal organ damage. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary question will investigate whether and, if so, which changes the concentrations of the above-mentioned EVs exhibit over time. | — |
Countries
Germany
Outcome results
None listed