F84.5 F84.1 F84.0
Conditions
Interventions
Group 1: Individuals with autism spectrum disorder
Study design [Participants are given the possibility to fill questionnaires online before their actual appointment at the institute. Measurements th
Franke et al., 2017)
3. Perceived Stress Questionnaire (PSQ
Fliege et al., 2009)
4. Autismusquotient Questionnaire (AQ
Baron-Cohen et al., 2006)
5. Sensory Perception Quotient (SPQ
Tavassoli et al, 2014)
6. ADHS-SB (Rösler et al., 2004)
7. Prosopagnosie Screening (Kennerknecht 2006 & 2008)
8. Modular Abbreviated Intelligence Test (M-KIT
Dantlgraber et al., 2015)
9. Abbreviated Working Memory Test (KAI-N
Hasselhorn et al., 2012)
10. Functional magnetic resonance imaging (fMRI) and eye-tracking during performing a category learning task with abstract patterns
11. Anatomical MRI scan
12. Questionnaire
Dantlgraber et al., 2015)
9. Abbreviated Working Memor
Sponsors
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: For individuals with autism-spectrum disorder: confirmed clinical diagnoses of autism-spectrum disorder. It is planned to calculate and report analyses including all participants as well as analyses including only those participants, who were able to learn the task (i.e,. performed above chance levels at the end of the training phase). To guarantee the desired sample size also for the latter analyses, an additional individual with autism plus two matching controls will be included for every individual with autism who did not successfully learn the task.
Exclusion criteria
Exclusion criteria: No mental retardation, no severe difficulties in verbal understanding, no current severe psychiatric or neurological disorder affecting cognitive functioning, no substance abuse. For individuals without autism, no suspicion of autism and no first-degree relative with autism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Goal of the study is the investigation of differences in the acquisition and representation of category knowledge in individuals with and without autism spectrum disorder. For this purpose, accuracy, reaction times, behavioral and neuronal model-fits, sensitivity parameter, neuronal correlates based on BOLD-effects from functional magnetic-resonance tomography data (one measurement point) should be used | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition to comparing the ASD and non-ASD groups, the acquisition and representation of category knowledge will be linked to autistic traits. Autistic traits will be investigated in both groups using the autism quotient questionnaire (Baron-Cohen et al., 2006). Baron-Cohen, S., Hoekstra, R. A., Knickmeyer, R., & Wheelwright, S. (2006). The autism-spectrum quotient (AQ)—adolescent version. Journal of autism and developmental disorders, 36(3), 343. | — |
Countries
Germany
Contacts
Public ContactJanine Bayer
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Outcome results
None listed