Examine the effects of combined high-intensity endurance and strength training in children, adolescents, and young adults undergoing hematologic stem cell transplantation.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00025995

Enrollment

Registered

2021-09-06

Start date

2022-01-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z94.81 Z94.80

Interventions

Group 1: The intervention group performs a complex training program with high-intensity endurance training, HIT and intensive strength training. The training is completed with mindfulness exercises. G

Eligibility

Sex/Gender

All

Age

8 Years to 25 Years

Inclusion criteria

Inclusion criteria: Female/Male HSCT Therapy Age: 8-25 years Signed consent form of the participants or legal representatives

Exclusion criteria

Exclusion criteria: Concomitant diseases that make training impossible pregnancy other factors that severely limit the ability to cooperate (highly impaired communication, serious psychiatric illnesses, etc.)

Design outcomes

Primary

Measure	Time frame
1. quality of life: physical, emotional, social and educational functioning (PedsQL). 2. physical performance with endurance (VO2peak, Pmax) and motor performance (coordination, flexibility and strength).	—

Secondary

Measure	Time frame
3. length of hospital stay: number and duration of inpatient stay. 4. stress echocardiography: (LV FS, LV EF, LVIDd, LVIDs and strain values of the left ventricle: GLS, a4c LS, a3c LS, a2c LS, SAX CS) 5. physical activity: step count recording via a wrist movement tracker 6. (Re-)integration in physical education (school, club) 7. training monitoring data: lactate, heart rate, subjective exertion level, cancer-related fatigue, subjective health status 8. occurrence/severity of concomitant diseases (toxicity, infection, GvHD) 9. anthropometry: height, body weight, body fat percentage, waist to height ratio (WHtR) 10. biomarkers: pro- and anti-inflammatory factors: IGF-1, PGC1-a, protein kinase A, mTOR, MIF, kynurenine, p53, IL10, TNF-alpha. 11. course of blood parameters: Platelets, hematocrit, hemoglobin, C-reactive protein, lymphocytes (T cells, B cells, Nk cells).	—

Measure

Time frame

3. length of hospital stay: number and duration of inpatient stay. 4. stress echocardiography: (LV FS, LV EF, LVIDd, LVIDs and strain values of the left ventricle: GLS, a4c LS, a3c LS, a2c LS, SAX CS) 5. physical activity: step count recording via a wrist movement tracker 6. (Re-)integration in physical education (school, club) 7. training monitoring data: lactate, heart rate, subjective exertion level, cancer-related fatigue, subjective health status 8. occurrence/severity of concomitant diseases (toxicity, infection, GvHD) 9. anthropometry: height, body weight, body fat percentage, waist to height ratio (WHtR) 10. biomarkers: pro- and anti-inflammatory factors: IGF-1, PGC1-a, protein kinase A, mTOR, MIF, kynurenine, p53, IL10, TNF-alpha. 11. course of blood parameters: Platelets, hematocrit, hemoglobin, C-reactive protein, lymphocytes (T cells, B cells, Nk cells).

—

Countries

Germany

Contacts

Public ContactSebastian Schulz

Sport- und Rehabilitationsmedizin

sebastian.schulz@uniklinik-ulm.de073150045359

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026