Fontan circulation
Conditions
Interventions
Group 1: During the study, patients with a fontane circulation are reduced to approximately 15.2% oxygen in the ambient air for about 24 to 36 hours, which results in an altitude exposure of approx. 2
Sponsors
Abteilung für Kinderkardiologie des Universitätsklinikums Bonn
Eligibility
Sex/Gender
All
Age
16 Years to 30 Years
Inclusion criteria
Inclusion criteria: - Hemodynamically stable Fontan patients (10 w; 10 m). - Age 16 to 30 years - Peripheral saustoff saturation = 90%. - Physical and mental ability to complete spiroergometry on a bicycle ergometer - Signed informed consent (If underage, also signed informed consent from both parents).
Exclusion criteria
Exclusion criteria: - Failing Fontan (protein-losing enteropathy, ascites, bronchitis plastica, NYHA stage III or IV). - Fenestration in the Fontan tunnel - Peripheral oxygen saturation < 90 % in normoxia - Stent in pulmonary artery, Glenn anastomosis and/or proximal tunnel of Fontan - Claustrophobia - smoker - Obesity (BMI = 30) - Cardiac pacemaker - Acute infections - Medication with sildenafil or bosentan - Medication with hypnotics - Known sleep disorders - Known depression, previous psychiatric illnesses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main objectives of the sleep study are: 1. to determine the minimum nocturnal value of peripheral oxygen saturation and the proportion of sleep time spent during which oxygen saturation falls below 85%. 2. polysomnographic recording of sleep in Fontan patients under moderate normobaric hypoxia exposure. In particular, the sleep efficiency and the proportion of different sleep stages and waking phases will be determined. 3. to collect first normative data for Fontan patients, which will then be compared with data from preliminary studies of healthy control subjects under hypoxia. | — |
Countries
Germany
Contacts
Public ContactNicole Müller
Abteilung für Kinderkardiologie des Universtätsklinikums Bonn
Outcome results
None listed