Proenkephalin as a guide to cessation of renal replacement therapy in the ICU: A single-center observational, prospective pilot study

Proenkephalin as a guide to cessation of renal replacement therapy in the ICU: A single-center observational, prospective pilot study - PROENK-Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025981

Enrollment

200

Registered

2021-08-16

Start date

2023-06-14

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury on ICU

Interventions

Group 1: - Proenkephalin (POCT) and other markers at end of dialysis - Proenkephalin (POCT) and other markers at dialysis end + 72h - Proenkephalin (POCT) and other markers at dialysis end + 72h + 96h

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Critically Ill patients in ICU with CRRT

Exclusion criteria

Exclusion criteria: Age < 18, no informed consent, no CRRT

Design outcomes

Primary

Measure	Time frame
Measurement of proenkephalin during CRRT - weaning. Subsequently, check whether weaning was successful (Yes / No).	—

Countries

Germany

Contacts

Public ContactSteffen Dickel

Klinik für AnästhesiologieUniversitätsmedizin Göttingen

steffen.dickel@med.uni-goettingen.de+4955166045

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026