F50.0
Conditions
Interventions
Group 1: Female anorectic patients (BMI index under the 10th age percentiles) take part in 2 appointments each for a pre and a post measurement:
1) a structured clinical assessment including psychome
Sponsors
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg
Eligibility
Sex/Gender
Female
Age
11 Years to 19 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria: - Female sex - Age between 11 to 19 years - Sufficient understanding of the German language - Informed consent from study participants and their legal guardians Inclusion Criteria Patient Group Anorexia Nervosa: - Diagnosis of anorexia nervosa according to ICD-10 F50.0 - Connection to outpatient, day-care or inpatient diagnosis/counseling/treatment at KJP Regensburg - BMI index below the 10th age percentile Inclusion criteria Control group: - No previous psychiatric or neurological illnesses - No presence of a mental disorder requiring treatment - No current or past outpatient, partial hospitalization, or full hospitalization psychiatric or psychotherapeutic interventions - BMI between 19 - 23.9
Exclusion criteria
Exclusion criteria: General Exclusion Criteria: - Pre-existing neurological or endocrinological disease - Pregnancy - Interlectual impairment (IQ < 80) - Comorbid profound developmental disorder (autism) - substance dependence - Taking a psychotropic medication - lack of consent - acute suicidal tendency - MRI-specific contraindications that preclude patient inclusion due to the strong magnetic field, including: Metallic foreign objects, tattoos with metal-containing pigments, claustrophobia, pacemakers and defibrillator systems, cochlear implant, implanted insulin pumps, non-removable piercings made of magnetic materials Exclusion criteria control group: - psychiatric pre-existing conditions - Presence of a mental disorder requiring treatment - Current or past outpatient, partial hospitalization, or full hospitalization psychiatric or psychotherapeutic interventions - BMI below 19.0
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim is to draw conclusions about possible cachexia-related structural and chemical changes in the context of anorexia nervosa as well as potential regeneration during the course of therapy or even chronic brain physiological consequences due to the massive weight loss and malnutrition. fMRI: Diffusion-weighted imaging (DTI) is used to assess structural connectivity differences between relevant areas. MR spectroscopic examination measures metabolic markers (GABA, glutamate, glutathione). | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychometric tests will be used to analyze possible comorbidities and other influencing factors. Questionnaires and clinical interview: - Baseline data interview on study-relevant data such as age/date of birth, nationality, weight, height, type of school, treatment setting, duration of illness, previous and current medication, eating behavior, and burden of current corona situation. - Mini-International Neuropsychiatric Interviews for Children and Adolescents (MINI-KID) (Sheehan et al., 1998). - Short form of the Structured Inventory for Anorexic and Bulimic Eating Disorders according to DSM-IV and ICD-10 of (SIAB-S) (Fichter & Quadflieg, 2001). - Eating Disorder Inventory-2 (EDI-2) (Paul & Thiel, 2005) - Beck Anxiety Inventory (BAI) (Beck et al., 1988) - Beck Depression Inventory (2nd edition) (BDI-II) (Beck, Steer, & Brown, 2006). - Edinburgh Handedness Inventory (EHI) (Oldfield, 1971). - Perth Alexithymia Questionnaire (PAQ) (Preece et al, 2018) - Body Perception Questionnaire (BPQ) (Porges, 1993) | — |
Countries
Germany
Contacts
Public ContactIrina Jarvers
Lehrstuhl für Kinder- und Jugendpsychiatrie und Psychotherapie
Outcome results
None listed