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Next generation urine diagnostics and monitoring- urine FACS in urinary tract infection

Next generation urine diagnostics and monitoring- urine FACS in urinary tract infection

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00025922
Enrollment
100
Registered
2021-07-21
Start date
2021-08-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N39.0 Z94.0

Interventions

Group 1: Kidney transplant patients without UTI. Urine sample analysis for immune cells, kidney cells, antibodies and bacteria at every regularly clinic visit, at least 3 times over the time course. G

Sponsors

Charité Campus Charité Mitte
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Kidney transplantation, follow up clinic visit

Exclusion criteria

Exclusion criteria: Acute rejection, Anuria, Nephrostomy, ileal conduit.

Design outcomes

Primary

MeasureTime frame
Main hypothesis: Microbiome and cell signature differ in kidney transplant patients with and without urinary tract infection. Analysis of differences is feasible by urine FACS.—

Secondary

MeasureTime frame
Other Hypotheses: -Urinays cell signatures and microbiome are significantly correlated -Urinary immune cell populations hold a predictive value for the development of UTI or relapse of UTI -Urinary cell signatures differ depending on bacteria colonization -Urinary cell populations differ in patients with asymptomatic bacteriuria and UTI -Urinary cell signatures and transplant function are significantly correlates during / after UTI—

Countries

Germany

Contacts

Public ContactNina Görlich

Charité Universitätsmedizin Berlin

nina.goerlich@charite.de004930450614369

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026