The neural correlates of action-perception coupling in schizophrenia: Impaired recalibration and cross-modal transfer of forward model predictions.

The neural correlates of action-perception coupling in schizophrenia: Impaired recalibration and cross-modal transfer of forward model predictions. - PACT_RE

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00025885

Enrollment

Registered

2021-07-23

Start date

2022-01-19

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F20 F22 F23 F25 F28 F29

Interventions

Group 1: Patient group: In the first part of the study, all patients perform an experiment to investigate sensorimotor recalibration in two separate fMRI sessions. In the second part of the study, al

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: - Patient group: diagnosis from the schizophrenia spectrum (see investigated disease/health problem) - Right-handedness - Informed consent

Exclusion criteria

Exclusion criteria: - Contraindications for fMRI and/or tDCS. - Brain injury or diagnosis of a medical or neurological disorder that could affect brain metabolism - Non-correctable visual or auditory impairments - Acute substance abuse - Diagnosis from the schizophrenia spectrum in a first-degree relative (control group) - Psychiatric diagnosis in the present or past (control group)

Design outcomes

Primary

Measure	Time frame
In both parts of the study: - Comparison of experimentally assessed sensorimotor recalibration effects between patients with schizophrenia and healthy control subjects. Study part 1 (fMRI): - Comparison of changes in neural activity due to sensorimotor recalibration (especially in the cerebellum and sensory areas) between patients with schizophrenia and healthy control subjects. Study part 2 (tDCS): - Improvements in recalibration effects in active conditions by tDCS of the cerebellum in patients with schizophrenia and healthy control subjects compared to the sham control condition. - Improvements in delay detection performance for active and passive conditions by tDCS of the angular gyrus in patients with schizophrenia and healthy control subjects compared to the sham control condition. - Increased active-passive differences by tDCS of the SMA in patients with schizophrenia compared to the sham control condition.	—

Measure

Time frame

In both parts of the study: - Comparison of experimentally assessed sensorimotor recalibration effects between patients with schizophrenia and healthy control subjects. Study part 1 (fMRI): - Comparison of changes in neural activity due to sensorimotor recalibration (especially in the cerebellum and sensory areas) between patients with schizophrenia and healthy control subjects. Study part 2 (tDCS): - Improvements in recalibration effects in active conditions by tDCS of the cerebellum in patients with schizophrenia and healthy control subjects compared to the sham control condition. - Improvements in delay detection performance for active and passive conditions by tDCS of the angular gyrus in patients with schizophrenia and healthy control subjects compared to the sham control condition. - Increased active-passive differences by tDCS of the SMA in patients with schizophrenia compared to the sham control condition.

—

Secondary

Measure	Time frame
- Comparison of recalibration effects between patients with schizophrenia showing hallucinations and ego-disturbances with patients without these symptoms. - Correlation of the extent of negative and positive symptoms (assessed by SANS and SAPS) with the extent of recalibration effects.	—

Countries

Germany

Contacts

Public ContactChristina Schmitter

Universitätsklinikum Gießen und Marburg

cschmit@med.uni-marburg.de06421-58-65837

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026