Tic Disorders: Persistent (Chronic) Motor Tic Disorder, Provisional Tic Disorder, Tourette's Disorder F95 F95.0 F95.1 F95.2
Conditions
Interventions
Group 1: Neurophysiological and brain network correlates of movement preparation and inhibition during typical development in children and adolescents.
-examination of movement correlated potentials
Sponsors
Medizinische Fakultät der Universität zu Köln
Eligibility
Sex/Gender
All
Age
5 Years to 16 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria - Healthy Participants -->No psychiatric diagnosis according to DSM-V -->between 5 and 16 years of age -->Consent to be informed of any incidental findings Inclusion criteria - Patients -->Tic disorder - Provisional Tic Disorder, Chronic Tic Disorder or Tourette-Syndrome according to DSM-V. -->between 5 and 16 years of age -->Consent to be informed of any incidental findings
Exclusion criteria
Exclusion criteria: --> IQEpileptic seizures (participant or parents) -->Other CNS-impairing neurological medical history -->Preterm birth before 32nd week of gestation -->Limited vision despite visual acuity correction -->Use of psychoactive substances (legal and illegal drugs) on the day of examination or with continued effects on the day of examination (depending on half-life) -->Use of stimulants on the day of examination or in case of retard products within the last 48 hours (for coffee or cigarette use 24 hours) -->Intake of antipsychotics or tranquilizers (each within 4half-lives). -->Fear of confinement -->Metal parts in or on the body (screws, metal-containing tattoos, non-removable piercings, cochlear implants, fixed braces with metal parts, etc.) -->Electrical devices in the body (pacemakers, medication pumps, etc.) -->Severe back pain, -->Excessive overweight -->Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG: The main outcome measure of study 1 (physiological maturation) is the reconstruction of the frontal sources of MRP or their development from age 5 to 16. Age-dependent differences in the brain areas involved provide information about the physiological maturation processes, as a result of which cortical motor control is formed. Main outcome measure of study 2 (tic disorder) is the reconstruction of the sources of tics (tic generator) in the MRP in distinction to the physiological maturation of voluntary movements (intraindividual and in comparison to the healthy group). (f)MRI: Main target variables of studies 1 and 2 are differential activation and connectivity patterns in SMA, dorsal premotor cortex, basal ganglia and cerebellum (task 1) and insular, cingulate and parietal operculum. | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG: -Describing the maturation of cortico-cortical connectivity as the motor system matures (coherence analysis, directed connectivity). -Description of MRP during voluntary tic inhibition (identification and maturation of networks for top-down control). -Capture of modification of TEP during preparation of voluntary movements in subjects with tic disorders (do positive MRP represent inhibition or other form of pre-activation, processing of tic-like movements triggered by TMS). (f)MRI Fronto-striatal, fronto-cerebellar functional connectivity (studies 1 and 2). | — |
Countries
Germany
Contacts
Public ContactTheresa Heinen
LFG Klinische Neuropsychologie des Kindes- und Jugendalters, Uniklinik RWTH Aachen
Outcome results
None listed