Frequency of near-death experiences, REM sleep behavior disorders, and other perception phenomena in patients with migraine with and without aura

Frequency of near-death experiences, REM sleep behavior disorders, and other perception phenomena in patients with migraine with and without aura - NDE-SS-Migraine

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025845

Enrollment

810

Registered

2022-01-24

Start date

2020-08-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G43.1 G43.0

Interventions

Group 1: Patients with migraine without aura and patients with migraine without aura will receive the following questionnaires as part of the study: 1. questionnaire about migraine diagnosis and char

2. questionnaire about visual phenomena, especially Visual Snow and Alice in Wonderland symptoms

3. questionnaire about near-death experiences. 4. questionnaire on REM sleep behavior disorders. 5. questionnaire about REM intrusions 6. questionnaire about depressiveness, anxiety and stress

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Presence of confirmed episodic or chronic migraine with or without aura according to International Headache Society (IHS) criteria. - Routine presentation at the Charité Headache Center - Sufficient knowledge of the German language to answer the questionnaires

Exclusion criteria

Exclusion criteria: - Severe psychiatric and/or neurological conditions that may affect study participation - Other known headache disorders - Regular use of more than 5 medications (polypharmacy)

Design outcomes

Primary

Measure	Time frame
Prevalence of NDEs (%) in patients with migraine with aura compared with patients with migraine without aura	—

Secondary

Measure	Time frame
Key secondary endpoints: - Prevalence of REM sleep behavior disorders (%), and specifically REM intrusions, in patients with migraine with aura compared with patients with migraine without aura. - Prevalence of NDEs (%) in patients with migraine with REM sleep behavior disorders compared with patients with migraine without REM sleep behavior disorders - Prevalence of visual snow symptoms (%) in patients with migraine with aura compared with patients with migraine without aura - Prevalence of AIWS (%) in patients with migraine with aura compared to patients with migraine without aura - Positive correlation between frequency of visual snow symptoms and DASS score - Positive correlation between frequency of AIWS and DASS score	—

Measure

Time frame

Key secondary endpoints: - Prevalence of REM sleep behavior disorders (%), and specifically REM intrusions, in patients with migraine with aura compared with patients with migraine without aura. - Prevalence of NDEs (%) in patients with migraine with REM sleep behavior disorders compared with patients with migraine without REM sleep behavior disorders - Prevalence of visual snow symptoms (%) in patients with migraine with aura compared with patients with migraine without aura - Prevalence of AIWS (%) in patients with migraine with aura compared to patients with migraine without aura - Positive correlation between frequency of visual snow symptoms and DASS score - Positive correlation between frequency of AIWS and DASS score

—

Countries

Germany

Contacts

Public ContactJasper Mecklenburg

Charité Campus Charité Mitte

kopfschmerz@charite.de030 450 660168

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026