G35
Conditions
Interventions
Group 1: Multiple Sclerosis patients
Conducting the following tests
BDI
FEAG
FEDA
MoCA
RCFD
WMSI-IV
RAVLT
ESS
EMQS
FIS-D
PSQI
SDMT
Data about EDSS, Date of diagnosis und MS-therapy
Group 2: Matche
Sponsors
Carl von Ossietzky Universität OldenburgAbteilung für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of multiple sclerosis according to the revised McDonald criteria (Thompson et al., 2018), all subgroups (relapsing remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and primary progressive multiple sclerosis (PPMS) will be eligible). Patients must be capable of being informed and must be able to sufficiently reflect on the decision to participate in the study; this criterion will be checked before the information is provided. EDSS < 3 Prerequisite for participation in the study is German as native language.
Exclusion criteria
Exclusion criteria: Signs of depression (BDI > 20) - Taking medications that modify memory performance (e.g., anticholinergics for treatment of bladder weakness) - Medical conditions beyond multiple sclerosis that may impair brain function. - A severe physical disability with an EDSS score >= 6, equivalent to a motor Disability resulting in a walking distance less than 100m. Presence of a psychiatric or neurological disorder. Regular use of medications that interact with CNS function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients with multiple sclerosis and mild disease expression show reduced memory performance in retaining verbal information (1st RAVLT retrieval after 7 days / RVLT retrieval after 30 min, 2nd WMSI retrieval after 7 days / WMSI retrieval after 30 minutes) and non-verbal information (3rd RCFT retrieval 7 days / RCFT retrieval 30 minutes) (H1 verbal, H2 non-verbal) after 7 days compared to age-, sex-, and education-matched healthy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| Disturbances in retaining information (verbal, non-verbal) over a long-term interval are caused by disturbed sleep-bound memory consolidation and therefore correlate with sleep score. Disturbances in retaining information (verbal or non-verbal) over a long-term interval objectify a subjectively experienced memory disturbance (questionnaire). Disturbances in retaining information (verbal or non-verbal) over a long-term interval are the consequence of a specific memory disturbance in the sense of a mild cognitive impairment. | — |
Countries
Germany
Contacts
Public ContactKarsten Witt
Carl von Ossietzky Universität OldenburgAbteilung für Neurologie
Outcome results
None listed