Immunohistochemical analysis of transcription intermediary factor-1? (TIF1-?) expression in the skin of adult anti-TIF1-? positive dermatomyositis patients

Immunohistochemical analysis of transcription intermediary factor-1? (TIF1-?) expression in the skin of adult anti-TIF1-? positive dermatomyositis patients - TIF1-? project

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00025768

Enrollment

Registered

2021-07-05

Start date

2021-09-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M33.1

Interventions

Group 1: TIF1 gamma positive dermatomyositis in adults (Immunohistochemical charakterization of the expression of TIF1-? in archived skin samples) Group 2: TIF1 gamma negative dermatomyositis in adult

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Diagnosed adult dermatomyositis - Serological evidence of TIF1-gamma available - Presence of an archived skin biopsy - Availability of patient data (clinical and serological)

Exclusion criteria

Exclusion criteria: No qualitative skin sample material available

Design outcomes

Primary

Measure	Time frame
Distribution of immunohistochemically measured expression (ordinal scale) of TIF1-? in skin samples from patients with TIF1-gamma positive adult dermatomyositis	—

Secondary

Measure	Time frame
1. Association between phenotype (clinical and serological patient characteristics) and TIF1-? expression in the skin. 2. Proportion of associated malignancies in patients with TIF1-? positive adult dermatomyositis. 3. Proportion of patients with TIF1-? expression in the skin in control group (patients with TIF1-? negative adult dermatomyositis)	—

Countries

Germany

Contacts

Public ContactTanya Meysman

Johannes Wesling Klinikum Universitätsklinik für Dermatologie, Venerologie, Allergologie und Phlebologie, UK der Ruhr-Universität Bochum

tanya.meysman@ruhr-uni-bochum.de+4957179054501

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026