Atopic dermatitis chronic urticaria
Conditions
Interventions
Group 1: A maximum of 30 adult patients each with chronic urticaria or atopic dermatitis will be included in the study.
Group 2: Healthy volunteers (max. 30 volunteers) will also be included in the st
Sponsors
Klinik für Dermatologe, Venerologie und AllergologieCharité - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. adults: = 18 and = 90 years old 2. disease activity: a. AD: vIGA = 3 and EASI score = 21. b. AD: Extrinsic AD (sensitisation to multiple environmental allergens). c. CU: UCT score = 12.
Exclusion criteria
Exclusion criteria: CU: With asthma or/and atopic dermatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the expression and relevance of pro-inflammatory factors in the skin and blood (by proteomic analysis, flow cytometry and histological examination of skin biopsies) in patients with inflammatory skin diseases. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. assess the correlation of disease-dependent pro-inflammatory factors and disease activity and duration. 2. investigate the correlation between disease-dependent molecular inflammatory pathways and drug response. 3. assess the identification of potential pharmacological targets using post hoc analysis of molecular data. | — |
Countries
Germany
Contacts
Public ContactMarcus Maurer
Klinik für Dermatologe, Venerologie und AllergologieCharité - Universitätsmedizin Berlin
Outcome results
None listed