Skin physiological changes during the combination of daylight PDT with fractional laser therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00025590

Enrollment

Registered

2021-08-25

Start date

2021-08-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L57.0

Interventions

Group 1: On the ventral right or left forearm of the patient, 4 fields each 3 x 3 cm are marked and selected at random (order of the Latin square) for the following test procedures: 1. Application of

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Men and women with actinic keratosis on the scalp

Exclusion criteria

Exclusion criteria: Men and women without actinic keratosis, pregnant women

Design outcomes

Primary

Measure	Time frame
Changes in skin physiological parameters on the forearm (TEWL, colorimetry, corneometry). P- "patient" - patient with actinic keratosis, skin of the forearm on the right or left. I - "Intervention" - 4 fields on the forearm (daylight PDT, fractional laser, daylight, daylight PDT with the fractional laser) C - "Comparison" - Each measurement is compared to the base measured value (time 0). O - Outcome - skin physiological measured values ??as delta value to the base value 0 minutes (before intervention): TEWL (barrier change, in g / m2 / h) Colorimetry erythema (a-values, taken from the L * a * b * units) Corneometry (skin moisture, in relative Corneometer® units) The delta values ??of a measurement time (30 minutes, 24 hours, 7 days and 14 days) are always compared to the base value of 0 minutes.	—

Measure

Time frame

Changes in skin physiological parameters on the forearm (TEWL, colorimetry, corneometry). P- "patient" - patient with actinic keratosis, skin of the forearm on the right or left. I - "Intervention" - 4 fields on the forearm (daylight PDT, fractional laser, daylight, daylight PDT with the fractional laser) C - "Comparison" - Each measurement is compared to the base measured value (time 0). O - Outcome - skin physiological measured values ??as delta value to the base value 0 minutes (before intervention): TEWL (barrier change, in g / m2 / h) Colorimetry erythema (a-values, taken from the L * a * b * units) Corneometry (skin moisture, in relative Corneometer® units) The delta values ??of a measurement time (30 minutes, 24 hours, 7 days and 14 days) are always compared to the base value of 0 minutes.

—

Secondary

Measure	Time frame
Reduction of actinic keratoses on the scalp under daylight PDT with the fractional laser. P - "patient" - patient with actinic keratosis, scalp I - "Intervention" - daylight PDT with the fractional laser (one side of the scalp) C - "Comparison" - daylight PDT without fractional laser (the other side of the scalp) O - "Outcome" - percent reduction in actinic keratosis Definition of the variables: aKvTh = number of actinic keratoses before therapy (is clinically counted) aKnTh = number of actinic keratoses after therapy (is counted clinically) EbaKnTH = successfully treated actinic keratoses after therapy (will be calculated - see below) RedaK = reduction of actinic keratoses in percent (is calculated - see below) EbaKnTH = aKvTh - aKnTh RedaK = EBAKnTH / aKvTh * 100	—

Measure

Time frame

Reduction of actinic keratoses on the scalp under daylight PDT with the fractional laser. P - "patient" - patient with actinic keratosis, scalp I - "Intervention" - daylight PDT with the fractional laser (one side of the scalp) C - "Comparison" - daylight PDT without fractional laser (the other side of the scalp) O - "Outcome" - percent reduction in actinic keratosis Definition of the variables: aKvTh = number of actinic keratoses before therapy (is clinically counted) aKnTh = number of actinic keratoses after therapy (is counted clinically) EbaKnTH = successfully treated actinic keratoses after therapy (will be calculated - see below) RedaK = reduction of actinic keratoses in percent (is calculated - see below) EbaKnTH = aKvTh - aKnTh RedaK = EBAKnTH / aKvTh * 100

—

Countries

Germany

Contacts

Public ContactNatalya Ilina

Klinik für Dermatologie, Allergologie und Phlebologie

Natalya.ilina@slk-kliniken.de07131 49-35001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026