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Acute effects of mental fatigue on gait performance and prefrontal oxygenation in haematological and oncological patients as a function of cancer-related fatigue

Acute effects of mental fatigue on gait performance and prefrontal oxygenation in haematological and oncological patients as a function of cancer-related fatigue

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00025549
Enrollment
24
Registered
2021-06-14
Start date
2021-10-01
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C00-C97 D47

Interventions

Group 1: Patients without or with mild fatiques symptoms (VAS 0-3) 1. Deadlines - Questionnaires (EORTC-QLQ-30, MFI-20, FESI, BPS-28, BSCS-13) - Performance diagnostics (cognitive status, body composi

Sponsors

Klinik III (Hämatologie, Onkologie, Palliativmedizin)Zentrum für Innere MedizinUniversitätsmedizin Rostock
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age between 60 and 80 years - Outpatients with a confirmed diagnosis ICD: C00 * - C97 * and D47 * (during or after therapy, chronic diseases) - able to walk without a walker - master the German language, spoken and written - The patient must be physically and psychosocially able to participate in the study (medical assessment) - MMSE = 24

Exclusion criteria

Exclusion criteria: - dependent on walking aid - musculoskeletal diseases of the lower extremities (e.g. severe osteoarthritis, dorsiflexion weakness) - Neurological diseases that affect gait (e.g. Parkinson's, stroke) - Polyneuropathy of all degrees of severity - Alcohol or drug addiction - Clinically significant cardiovascular and / or lung diseases (recent myocardial infarction ( stage 2a according to Fontaine - Serious or uncontrollable medical conditions (e.g. diabetes, acute or chronic liver disease, pancreatic or severe kidney disease unrelated to a tumor and acute or uncontrollable infections) - recent thrombosis / pulmonary embolism - patients unable to give consent - did not meet all inclusion criteria

Design outcomes

Primary

MeasureTime frame
Coefficient of variation (CV) of gait speed Influence of acute mental fatigue on the gait parameters during dual-task walking haematological and oncological patients depending on the degree of CrF

Secondary

MeasureTime frame
- Influence of acute mental fatigue on gait parameters for single-task walking - Analysis of the variation in walking speed after a mentally tiring task depending on the level of CrF - Influence of a sustained cognitive task (active vs. passive task) on the oxygenation of the prefrontal cortex -Influence of acute mental fatigue on the oxygenation of the prefrontal cortex during single-task walking - Influence of acute mental fatigue on the oxygenation of the prefrontal cortex during dual-task walking - Relationship between mental fatigue (acute) and CrF (chronic) - Relationship between mental fatigue and the perception of boredom depending on susceptibility to boredom Relationship between mental fatigue and self-control - Relationship between gait parameters and fear of falling - Relationship between gait parameters and CrF - Relationship between gait parameters and muscle mass - Correlation between gait parameters and performance in the 30-second "sit-to-stand test" - Relationship between gait parameters and hand grip strength - Relationship between gait parameters and performance in the "timed-up-and-go test" - Relationship between gait parameters and QoL - Analysis of predictors for the single-task gait variability - Analysis of predictors for the dual-task gait variability

Countries

Germany

Contacts

Public ContactSabine Felser

Klinik III (Hämatologie, Onkologie, Palliativmedizin)Zentrum für Innere MedizinUniversitätsmedizin Rostock

sabine.felser@med.uni-rostock.de0381 494 7395

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026